Background: Cardiopulmonary Bypass (CPB) application may cause severe hemodilution and an acute systemic inflammatory response syndrome, especially with blood components transfusion. Multi-function circuit of cardioplegia delivery, conventional ultrafiltration, and modified ultrafiltration was advocated to reverse the CPB hemodilution and conserve patient’s blood through a blood conservation protocol.
Methods: Retrospectively, 600 pediatric were randomly and equally distributed into six studied (S) and control (C) groups. Groups had been classified according to weights as following; 30 kg≥ groups IS and IC >20 kg≥ groups IIS and IIC >10 kg≥ groups IIIS and IIIC ≥3kg, only studied groups were treated with the blood conservation protocol. The fluid management, blood components conservation, and pediatrics clinical outcome characteristics will be investigated in this study.
Results: 100% achievements for zero fluids balance and bloodless surgery for studied pediatrics of weights ≥6 kg with significant autotransfusion amounts of RBCs, plasma and total protein (p<0.02). Studied pediatrics of weights <6 kg received a significantly lesser amount of homologous packed red blood cells, fresh frozen plasma, platelets (p<0.05) and protein product (p<0.01) compared with control pediatrics. Studied groups showed a gradual increase in mean arterial pressure during modified ultrafiltration process, with significant lesser collectively total dopamine dose (p<0.05 and p<0.02 for weights range of 30-6 kg and <6 kg respectevely). Significant lower blood loss (p<0.01) and shorter intubation duration and ICU stay (p<0.05 for group IS and p<0.01 for groups IIS and IIIS) observed for the studied groups.
Conclusion: The blood conservation protocol under investigation is a successful method using routine CPB unit components facilitating bloodless surgery for pediatric weights range of 6-30kg.
Keywords:
Published on: Feb 25, 2020 Pages: 1-12
Full Text PDF
Full Text HTML
DOI: 10.17352/ach.000023
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."