Micronucleus scoring: An available approach in the evaluation of genomic damage in exfoliative cervicovaginal cells

Zehra SAFI OZ*

Micronucleus is small chromatin extranuclear bodies when chromosomes or chromosomal fragments are not included in the nucleus during cell division. Micronucleus formation usually serves as a sensible indicator of genotoxic damage and also a morphological marker of chromosomal instability. Genomic damage is crucial for the development of degenerative diseases, including cancer. MN assay is a reliable and applicable method on many cell types such as erythrocytes, leucocytes and epithelial cells and it represents an important tool for evaluating DNA damage and defects in mitosis. The purpose of this article is to provide an overview of the current status of the micronuclei scoring in exfoliated epithelial cells and to highlight the importance of this procedure. 

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Published on: Jun 22, 2020 Pages: 64-67

Full Text PDF Full Text HTML DOI: 10.17352/acp.000018
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