Nutritional intervention for cancer sarcopenia

Takuya Mori, Akira Kido, Isao Kawahara, Shota Nuaga, Yoshihiro Miyagawa, Kei Goto, Shiori Mori, Shingo Kishi, Kiyomu Fujii, Rina Fujiwara-Tani and Hiroki Kuniyasu*

Most patients with advanced cancer develop skeletal muscle atrophy called sarcopenia, which reduces treatment tolerance and social activity and worsens the prognosis. Glucose suppresses skeletal muscle atrophy in cancer-bearing mice, while promoting cancer growth. In contrast, medium-chain fatty acids reduce skeletal muscle atrophy and suppress cancer growth. Simultaneous administration of glucose and medium-chain fatty acids suppresses skeletal muscle atrophy and eliminates the tumor growth seen in glucose. Based on these findings, dietary intervention using a combination of glucose and medium-chain fatty acids is expected to be effective in suppressing sarcopenia in cancer patients.

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Published on: Jan 6, 2021 Pages: 1-4

Full Text PDF Full Text HTML DOI: 10.17352/amm.000024
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