Background and aims: It was investigated whether there is a relationship between advanced atherosclerosis of the carotid artery and cancer.
Method: The carotid Total Plaque Area (TPA), the maximum plaque thickness, and the cardiovascular risk based on Framingham calculator using body-mass-index were determined in healthy subjects using ultrasound.
We compared the outcome in subjects with advanced atherosclerosis of the carotid artery (type III-IV b finding) with and without statin treatment. The follow-up was collected as part of occupational health check-ups.
Result: In 4207 healthy men aged 35-65 years (50±8 years) we found 578 subjects with advanced atherosclerosis of the carotid artery (type III-IV b finding). A follow-up was available for 566 (97.9%) subjects. The average follow-up time was 48 months (range 0 to 139 months). Ten subjects were excluded because of missing data on treatment. A total number of 230 subjects was treated with a statin, 326 received no statin. Within the group of these subjects (54±6 years), 33 men died (15 cancer, 4 strokes, 11 heart attacks, 1 COPD, 1 sepsis, 1 cirrhosis of the liver).
In the group with CVD death, two subjects were treated with a statin, 13 were untreated. In the group with cancer death, two subjects were treated with a statin, 13 were untreated. The death rate because of cancer and CVD was 1.7% for the treated subjects and 8.0% for the untreated subjects.
In the group with low risk (n= 1890), six men died (2 traffic accidents, 1aneurysm bleeding, 2 cancer, 1 unclear, a follow-up examination has been completed for 43.9% (n= 830) of the subjects, mean follow-up time of 65 months (0-137 months). One man died (Parkinson) within the group with intermediate risk. In this group (n= 482) a follow-up examination has been completed for 55% (n= 265) with a mean follow-up time of 55 months (total range: 0-130 months). In the reference group (no atherosclerosis; n= 1257) follow-up has been completed in 38.3% (n= 482) with a mean follow-up time of 60 (0-145) months and nobody died.
In 3203 healthy women aged 35-65 years nobody died of cancer.
Conclusion: The development of cancer in men with advanced atherosclerosis of the carotid artery appears to be noticeable. The question of whether there is a causal relationship requires further investigations.
Published on: Mar 25, 2022 Pages: 1-6
Full Text PDF
Full Text HTML
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
William CS Cho
Queen Elizabeth Hospital, Hong Kong
International Journal of Immunotherapy and Cancer Research
Jose Manuel Ramia-Angel
Guadalajara University Hospital , Spain
Journal of Surgery and Surgical Research
Wei Min HUANG
Nanyang Technological University, Singapore
Archive of Biomedical Science and Engineering
Istituto per lo studio delle psicoterapie (ISP), Italy
Open Journal of Trauma
Arghya Narayan Banerjee
Yeungnam University, South Korea
International Journal of Nanomaterials, Nanotechnology and Nanomedicine
Saint Joseph Hospital , Germany
Journal of Neurology, Neurological Science and Disorders
University of Reims, France
Archives of Sports Medicine and Physiotherapy
Prof. Pierre Guertin
Laval University, Canada
International Journal of Pharmaceutical Sciences and Developmental Research
University of Genoa, Italy
Global Journal of Allergy
Nikolaos A Chrysanthakopoulos
National and Kapodistrian University of Athens , Greece
Journal of Dental Problems and Solutions
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."