Results of a preliminary study on the effects of a compound on telomeres length, biological and physiological parameters

Christophe de Jaeger*, Carla Lamberti, Virginie Van Leeuwen, Elena Voronska and Saskia Kruiskamp

Telomeres are ribonucleoprotein structures forming a protective buffer at the ends of chromosomes. They preserve the integrity of the genetic material during the cell cycle. Replicative telomere erosion can be compensated by a telomerase. The average size of telomeres is a marker of the biological age of individuals and their exposure to various physiological and pathological conditions. We are reporting the findings of an open prospective pre-study in healthy volunteers of a new association of molecules on telomere elongation and its cardiovascular action. Ten healthy volunteers (6 men, 4 women), average age 59.4 ± 8.19 years old, with no specific history. This pre-study did reveal significant results concerning the size of the average and median telomeres. The speed of the propagation of the pulse wave on the carotid- femoral and arterial segment shows a reduction (8.74 ± 1.72 m / s at T0 for the 10 subjects, versus 8.18 ± 2.18 at M6). The study shows a significant improvement of the average PAO of 10 subjects, from 1.51 ± 0.13 mmol / l to T0, versus 1.68 ± 0.16 mmol / l at M1 (p <0.0006) and 1.58 ± 0.18 mmol / l at M6 (p <0.05).

Keywords:

Published on: Feb 17, 2021 Pages: 8-15

Full Text PDF Full Text HTML DOI: 10.17352/jbm.000025
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat