Background: The multivariate analysis distinguishes components or factors and establishes associations among antibiotics based on their different levels of correlation.
Objectives: A dendrogram analysis utilizing the clustering algorithm and comparative multivariate analysis on the Minimum Inhibitory Concentration (MICs) of eleven antibiotics, including the vancomycin, was performed.
Methods: A sum of 37 phenotypic resistance profile of S. aureus [10 methicillin-resistant S. aureus (MRSA)], isolated from various community settings of university campuses including Guru Angad Dev Veterinary and Animal Sciences University (GADVASU) and Punjab Agriculture University (PAU), were preselected.
Results: The detection of isolates with elevated MICs against oxacillin, ceftriaxone, tetracycline, and vancomycin suggests the emergence of multidrug-resistant S. aureus isolates resistant to an expanded number of antibiotics. From the dendrogram analysis, an approximate number of unique resistance profiles were 24 and arbitrarily circulated. No relationship or clustering of the resistance profile of isolates was observed. There were no outliers either concerning the sample. On Principal Component Analysis (PCA), the first factor had strong positive loadings on oxacillin, clindamycin, ceftriaxone, erythromycin, ciprofloxacin and trimethoprim-sulphamethoxazole and is largely a concern because of their clinical relevance. The second factor had strong loading on tetracycline and the third factor had a strong loading on Vancomycin (VAN). The first four components defined approximately 71% of the total variance and could easily be represented graphically in a three dimensional scatter plot. In this graphic representation, the eleven antibiotics clustered in four different spatial regions; tetracycline and vancomycin occupied separate spatial positions.
Conclusions: The use of dendrogram and multivariate analysis offers a different approach to draw the inferences from antibiotic MICs and draw some new findings on the relationships between different antibiotic classes.
Keywords:
Published on: Jun 23, 2020 Pages: 15-19
Full Text PDF
Full Text HTML
DOI: 10.17352/ojtm.000014
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."