Research Interest: Analytical Probe and Protein Biotechnology (a branch of chemical biology) Based on physicochemical principle for interactions of proteins with their ligands, chemometrics is utilized to mine information associated with the forces of their interactions, the strength for their bioaffinity interactions (affinities), the quantities of counterpart biomolecules, which facilitates the development of methods and probes for in vitro diagnostics and drug screening, protein ligands and protein mutants of biological significance. In detail, our research interest covers the following topics:

(1) New methods and probes for in vitro diagnostics and drug screening: to enhance analytical efficiency and precision, probes are designed based on mechanistic ways of bioaffinity interactions and new process to mine information are developed; such new methods and probes are applied to simultaneous assays of multiple components in single channel, especially for simultaneous immunoassays of multiple components in single channel, the screening of ligand mixtures, the screening of enzyme mutants, homogenous bioaffinity assay with tryptophan residues as resonance-energy-transfer donors, and linear response by competitive bioaffinity assay;

(2) With PDE and GST as examples, methods are developed to rational and combinatorial design of isozyme-selective inhibitors, pro-inhibitors and soft inhibitors, the screening of such inhibitors, and the potential as therapeutic agents;

(3) With uricase, arylsulfatase and alkaline phosphatase as examples, rational design and directed evolution of enzymes are studied, together with high-throughput screening and evaluation of their mutants, chemical modification of proteins; rational design of fused proteins as therapeutic agents;

(4) Affinity-labeling and site-specific immobilization of protein targets, the cross-linking/conjugation of enzymes and antibodies.

Research Interest: Screening small molecules that inhibit signaling pathways in cancer; Studying DNA damage and repair, cell cycle control, apoptosis and autophagy in cancer; Studying roles of protein modifications such as phosphorylation and ubiquitination in cancer; Investigating the roles of DNA polymerase epsilon (Polε) in telomere length maintenance

Research Interest: Metallic nanomaterials; Gold nanoparticles; Elemental mass spectrometry; Analytical chemistry; Atomic spectrometry

Research Interest: Spectrophotometry, Spectrofluorimetry, High performance liquid chromatography, Atomic absorption spectrophotometry

Research Interest: Tuberculosis ,Infectious Diseases, M.tuberculosis, Proteomics and related Bioinformatics, Electrophoresis, SDS-PAGE, 2D gel electrophoresis, Cloning, Expression, Purification, Molecular Modelling, Docking, Post translational modifications, Pupylation, Protein extraction and method devlopment for 2D, Mass Spectrometry, MALDI-TOF/MS and MS/MS etc

Research Interest: Synthesis of anostructured  materials (e.g.Gold nanoparticles, Carbon Nanotube, QDs), Assembly of biomimetic nanomaterial and photoelectric chemical  analysis, Development of protein and cell based electrochemical biosensors for medical diagnostics, Fundamental  Understanding  of DNAs, Antibodies, DNAzymes and Their  Applications  as Sensing and Imaging Agents in Environmental Monitoring and Medical Diagnostics

Research Interest: Arthritis, Stress, Neuropharmacology, Diabetes

Research Interest: Fluorescent chemosensors, nanomaterials (nanoparticles, nanorods, nanofibers, nanocomposites), heavy-metal(Ag+, Pb2+, Hg2+) ion sorbents, and ion-selective electrodes of intrinsically electrically conducting/conjugated polymers from aniline, pyrrole, thiophene, pyrene, triphenylene, and their derivatives; Synthesis of functional polymers, polymer chemistry; Liquid-crystalline aromatic polyesters and cholesteric cellulose derivatives; Water treatment and purification, Separation membrane science

Research Interest: Fluorescent Sensors for HTM,On line coupled GC/MS or LC-MS/MS analysis of POPs

Research Interest: Chemical sensors,Flow injection analysis,Drug analysis,Food safety analysis,Chemometrics,Robust statistics, Correspondence analysis, Three-way data analysis, Multivariate calibration, Second-order calibration, Second-order standard addition method，Multilinear decomposition，Multiway calibration,Novel applications of multi-way data analysis and multiway calibration methodologies to analytical, environmental, biological, drug, medical, food and life sciences,Quantitative analysis of proteins, metabonomics,Multi-way data analysis in automation and control systems

Research interest: Bibliometric and adsorption

Publications:

1.    Ho, Y.S.* (2016), Comments on the paper “Simultaneous removal of mixed contaminants by organoclays - Amoxicillin and Cu(II) from aqueous solution”. Applied Clay Science, 126, 297298. DOI: 10.1016/j.day.2016.03.031.  

Document type: Article     Language: English     Cited references: 18     Times cited: 3  

2.    Zhang, L., Hong, S., He, J., Gan, F.X. and Ho, Y.S.* (2011), Adsorption characteristic studies of phosphorus onto laterite. Desalination and Water Treatment, 25 (1), 98-105. DOI:

10.5004/dwt.2011.1871.  

Document type: Article     Language: English     Cited references: 17     Times cited: 35  

3.    Malarvizhi, R. and Ho, Y.S.* (2010), The influence of pH and the structure of the dye molecules on adsorption isotherm modeling using activated carbon. Desalination, 264 (1-3), 97-101. DOI: 10.1016/j.desal.2010.07.010.

Document type: Article     Language: English     Cited references: 21     Times cited: 63  

4.    Zhang, L., Hong, S., He, J., Gan, F.X. and Ho, Y.S.* (2010), Isotherm study of phosphorus uptake from aqueous solution using aluminum oxide. Clean-Soil Air Water, 38 (9), 831-836. DOI: 10.1002/clen.200900305.  

Document type: Article     Language: English     Cited references: 17     Times cited: 18  

5.    El-Khaiary, M.I., Malash, G.F. and Ho, Y.S.* (2010), On the use of linearized pseudo-secondorder kinetic equations for modeling adsorption systems. Desalination, 257 (1-3), 93-101. DOI: 10.1016/j.desal.2010.02.041.  

Document type: Article     Language: English     Cited references: 23     Times cited: 113  

6.    He, J., Hong, S., Gan, F.X., Zhang, L. and Ho, Y.S.* (2010), Equilibrium and thermodynamic parameters of adsorption of Methylene blue onto rectorite. Fresenius Environmental Bulletin, 19 (11A), 2651-2656.  

Document type: Article     Language: English     Cited references: 29     Times cited: 82  

7.    Hong, S., Wen, C., He, J., Gan, F.X. and Ho, Y.S.* (2009), Adsorption thermodynamics of Methylene Blue onto bentonite. Journal of Hazardous Materials, 167 (1-3), 630-633. DOI: 10.1016/j.jhazmat.2009.01.014.  

Document type: Article     Language: English     Cited references: 21     Times cited: 200  

8.    Zhang, J., Xie, S.D. and Ho, Y.S.* (2009), Removal of fluoride ions from aqueous solution using modified attapulgite as adsorbent. Journal of Hazardous Materials, 165 (1), 218-222. DOI: 10.1016/j.jhazmat.2008.09.098.  

Document type: Article     Language: English     Cited references: 34     Times cited: 70  

9.    Ho, Y.S.* (2009), Comments on “Adsorption of direct dyes from aqueous solutions by carbon nanotubes: Determination of equilibrium, kinetics and thermodynamics parameters”. Journal of Colloid and Interface Science, 333 (1), 412. DOI: 10.1016/j.jcis.2009.01.025.  

Document type: Article     Language: English     Cited references: 8     Times cited: 2  

10.    Ofomaja, A.E. and Ho, Y.S.* (2008), Effect of temperatures and pH on Methyl violet biosorption by mansonia wood sawdust. Bioresource Technology, 99 (13), 5411-5417. DOI:

10.1016/j.biortech.2007.11.018.

Document type: Article     Language: English     Cited references: 22     Times cited: 147  

11.    Ho, Y.S.* and Wang, C.C. (2008), Sorption equilibrium of mercury onto ground-up tree fern.

Journal of Hazardous Materials, 156 (1-3), 398-404. DOI: 10.1016/j.jhazmat.2007.12.030.  

Document type: Article     Language: English     Cited references: 56     Times cited: 53  

12.    Ofomaja, A.E. and Ho, Y.S.* (2008), Kinetic biosorption study of cadmium onto coconut copra meal as biosorbent. International Journal of Environment and Pollution, 34 (1-4), 466476. DOI: 10.1504/IJEP.2008.020810.  

Document type: Article     Language: English     Cited references: 32     Times cited: 9  

13.    Ofomaja, A.E. and Ho, Y.S.* (2007), Effect of pH on cadmium biosorption by coconut copra meal. Journal of Hazardous Materials, 139 (2), 356-362. DOI: 10.1016/j.jhazmat.2006.06.039.  

Document type: Article     Language: English     Cited references: 32     Times cited: 137  

14.    Ofomaja, A.E. and Ho, Y.S.* (2007), Equilibrium sorption of anionic dye from aqueous solution by palm kernel fibre as sorbent. Dyes and Pigments, 74 (1), 60-66. DOI:

10.1016/j.dyepig.2006.01.014.

Document type: Article     Language: English     Cited references: 36     Times cited: 180  

15.    Ho, Y.S.* and Ofomaja, A.E. (2006), Kinetic studies of copper ion adsorption on palm kernel fibre. Journal of Hazardous Materials, 137 (3), 1796-1802. DOI: 10.1016/j.jhazmat.2006.05.023.  

Document type: Article     Language: English     Cited references: 25     Times cited: 87  

16.    Ho, Y.S.* and Ofomaja, A.E. (2006), Biosorption thermodynamics of cadmium on coconut copra meal as biosorbent. Biochemical Engineering Journal, 30 (2), 117-123. DOI:10.1016/j.bej.2006.02.012.

Document type: Article     Language: English     Cited references: 28     Times cited: 209

17.    Ho, Y.S.* and Ofomaja, A.E. (2006), Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fiber. Journal of Hazardous Materials, 129 (1-3), 137-142. DOI: 10.1016/j.jhazmat.2005.08.020.

Document type: Article     Language: English     Cited references: 24     Times cited: 282  

18.    Ho, Y.S.* (2006), Isotherms for the sorption of lead onto peat: Comparison of linear and nonlinear methods. Polish Journal of Environmental Studies, 15 (1), 81-86.  

Document type: Article     Language: English     Cited references: 11     Times cited: 295  

19.    Ho, Y.S.* (2006), Second-order kinetic model for the sorption of cadmium onto tree fern: A comparison of linear and non-linear methods. Water Research, 40 (1), 119-125. DOI:

10.1016/j.watres.2005.10.040.

Document type: Article     Language: English     Cited references: 21     Times cited: 1039

20.    Ho, Y.S.*, Harouna-Oumarou, H.A., Fauduet, H. and Porte, C. (2005), Kinetics and model building of leaching of water-soluble compounds of Tilia sapwood. Separation and Purification Technology, 45 (3), 169-173.

Document type: Article     Language: English     Cited references: 13     Times cited: 54

21.    Ho, Y.S.* and Ofomaja, A.E. (2005), Kinetics and thermodynamics of lead ion sorption on palm kernel fibre from aqueous solution. Process Biochemistry, 40 (11), 3455-3461. DOI:

10.1016/j.procbio.2005.02.017.

Document type: Article     Language: English     Cited references: 22     Times cited: 175

22.    Ho, Y.S.*, Chiu, W.T. and Wang, C.C. (2005), Regression analysis for the sorption isotherms of basic dyes on sugarcane dust. Bioresource Technology, 96 (11), 1285-1291. DOI:

10.1016/j.biortech.2004.10.021.

Document type: Article     Language: English     Cited references: 31     Times cited: 428  

23.    Ho, Y.S.* (2005), Effect of pH on lead removal from water using tree fern as the sorbent.

Bioresource Technology, 96 (11), 1292-1296. DOI: 10.1016/j.biortech.2004.10.011.  

Document type: Article     Language: English     Cited references: 15     Times cited: 175  

24.    Ho, Y.S.* and Ofomaja, A.E. (2005), Effects of calcium competition on lead sorption by palm kernel fibre. Journal of Hazardous Materials, 120 (1-3), 157-162. DOI: 10.1016/j.jhazmat.2004.12.027.  

Document type: Article     Language: English     Cited references: 26     Times cited: 28  

25.    Ho, Y.S.* (2005), Comment on “Nitrate removal from aqueous solution by adsorption onto various materials” by N. Öztürk, T.E. Bektaş. Journal of Hazardous Materials, 118 (1-3), 253254. DOI: 10.1016/j.jhazmat.2004.10.015.

Document type: Article     Language: English     Cited references: 13     Times cited: 5

26.    Ho, Y.S.* (2005), Comments on “Chitosan functionalized with 2[-bis-(pyridylmethyl) aminomethyl]4-methyl-6-formyl-phenol: Equilibrium and kinetics of copper(II) adsorption”.Polymer, 46 (5), 1451-1452. DOI: 10.1016/j.polymer.2004.11.109.

Document type: Article     Language: English     Cited references: 17     Times cited: 4

27.    Ho, Y.S.*, Chiang, T.H. and Hsueh, Y.M. (2005), Removal of basic dye from aqueous solution using tree fern as a biosorbent. Process Biochemistry, 40 (1), 119-124. DOI: 10.1016/j.procbio.2003.11.035.

Document type: Article     Language: English     Cited references: 23     Times cited: 338  

28.    Ho, Y.S. and McKay, G. (2004), Sorption of copper(II) from aqueous solution by peat. Water Air and Soil Pollution, 158 (1), 77-97. DOI: 10.1023/B:WATE.0000044830.63767.a3.  

Document type: Article     Language: English     Cited references: 68     Times cited: 136  

29.    Ho, Y.S.* (2004), Pseudo-isotherms using a second order kinetic expression constant.

Adsorption-Journal of the International Adsorption Society, 10 (2), 151-158. DOI:

10.1023/B:ADSO.0000039870.28835.09.

Document type: Article     Language: English     Cited references: 21     Times cited: 120

30.    Ho, Y.S.*, Chiu, W.T., Hsu, C.S. and Huang, C.T. (2004), Sorption of lead ions from aqueous solution using tree fern as a sorbent. Hydrometallurgy, 73 (1-2), 55-61. DOI: 10.1016/j.hydromet.2003.07.008.

Document type: Article     Language: English     Cited references: 19     Times cited: 186  

31.    Ho, Y.S.* and Wang, C.C. (2004), Pseudo-isotherms for the sorption of cadmium ion onto tree fern. Process Biochemistry, 39 (6), 759-763. DOI: 10.1016/S0032-9592(03)00184-5.  

Document type: Article     Language: English     Cited references: 17     Times cited: 171  

32.    Ho, Y.S.* (2003), Removal of metal ions from sodium arsenate solution using tree fern.

Process Safety and Environmental Protection, 81 (B5), 352-356. DOI: 10.1205/095758203770224388.  

Document type: Article     Language: English     Cited references: 15     Times cited: 18  

33.    Ho, Y.S.* (2003), Removal of copper ions from aqueous solution by tree fern. Water Research , 37 (10), 2323-2330. DOI: 10.1016/S0043-1354(03)00002-2.  

Document type: Article     Language: English     Cited references: 18     Times cited: 566  

34.    Ho, Y.S. and McKay, G. (2003), Sorption of dyes and copper ions onto biosorbents. Process Biochemistry, 38 (7), 1047-1061. DOI: 10.1016/S0032-9592(02)00239-X.  

Document type: Article     Language: English     Cited references: 29     Times cited: 370  

35.    Ho, Y.S.*, Huang, C.T. and Huang, H.W. (2002), Equilibrium sorption isotherm for metal ions on tree fern. Process Biochemistry, 37 (12), 1421-1430. DOI: 10.1016/S0032-9592(02)00036-5.

Document type: Article     Language: English     Cited references: 25     Times cited: 458

36.    Ho, Y.S. and McKay, G. (2002), Application of kinetic models to the sorption of copper(II) on to peat. Adsorption Science & Technology, 20 (8), 797-815. DOI:10.1260/026361702321104282.

Document type: Article     Language: English     Cited references: 46     Times cited: 309

37.    Ho, Y.S., Porter, J.F. and McKay, G. (2002), Equilibrium isotherm studies for the sorption of divalent metal ions onto peat: Copper, nickel and lead single component systems. Water Air and Soil Pollution, 141 (1-4), 1-33. DOI: 10.1023/A:1021304828010.

Document type: Article     Language: English     Cited references: 59     Times cited: 962

38.    Ho, Y.S.* and Chiang, C.C. (2001), Sorption studies of acid dye by mixed sorbents.

Adsorption-Journal of the International Adsorption Society, 7 (2), 139-147. DOI:

10.1023/A:1011652224816.

Document type: Article     Language: English     Cited references: 31     Times cited: 374

39.    Ho, Y.S., Ng, J.C.Y. and McKay, G. (2001), Removal of lead(II) from effluents by sorption on peat using second-order kinetics. Separation Science and Technology, 36 (2), 241-261. DOI:

10.1081/SS-100001077.

Document type: Article     Language: English     Cited references: 48     Times cited: 248

40.    Ho, Y.S.*, Chiang, C.C. and Hsu, Y.C. (2001), Sorption kinetics for dye removal from aqueous solution using activated clay. Separation Science and Technology, 36 (11), 2473-2488. DOI:

10.1081/SS-100106104.

Document type: Article     Language: English     Cited references: 31     Times cited: 160

41.    Ho, Y.S. and McKay, G. (2000), Batch sorber design using equilibrium and contact time data for the removal of lead. Water Air and Soil Pollution, 124 (1-2), 141-153. DOI: 10.1023/A:1005218411809.

Document type: Article     Language: English     Cited references: 28     Times cited: 39

42.    Ho, Y.S. and McKay, G. (2000), Correlative biosorption equilibria model for a binary batch system. Chemical Engineering Science, 55 (4), 817-825. DOI: 10.1016/S0009-2509(99)00372-3.

Document type: Article      Language: English     Cited references: 19     Times cited: 49  

43. Ho, Y.S.      and McKay, G. (2000), The kinetics of sorption of divalent metal ions onto sphagnum

moss peat. Water Resear    ch, 34 (3), 735-742. DOI: 10.1016/S0043-1354(99)00232-8.  

Document type: Article      Language: English     Cited references: 11     Times cited: 2341  

44.    Ho, Y.S., McKay, G., Wase, D.A.J. and Forster, C.F. (2000), Study of the sorption of divalent metal ions on to peat. Adsorption Science & Technology, 18 (7), 639-650. DOI: 10.1260/0263617001493693.

Document type: Article     Language: English     Cited references: 28     Times cited: 570

45.    Ho, Y.S. and McKay, G. (1999), Competitive sorption of copper and nickel ions from aqueous solution using peat. Adsorption-Journal of the International Adsorption Society, 5 (4), 409417. DOI: 10.1023/A:1008921002014.

Document type: Article     Language: English     Cited references: 39     Times cited: 124  

46.    Ho, Y.S. and McKay, G. (1999), Pseudo-second order model for sorption processes. Process Biochemistry, 34 (5), 451-465. DOI: 10.1016/S0032-9592(98)00112-5.  

Document type: Article     Language: English     Cited references: 85     Times cited: 11401  

47.    Ho, Y.S. and McKay, G. (1999), Batch lead(II) removal from aqueous solution by peat:

Equilibrium and kinetics. Process Safety and Environmental Protection, 77 (B3), 165-173.

DOI: 10.1205/095758299529983.

Document type: Article     Language: English     Cited references: 49     Times cited: 108

48.    Ho, Y.S. and McKay, G. (1999), A kinetic study of dye sorption by biosorbent waste product pith. Resources, Conservation and Recycling, 25 (3), 171-193. DOI: 10.1016/S00431354(98)00207-3.

Document type: Article     Language: English     Cited references: 19     Times cited: 272  

49.    Ho, Y.S.* and McKay, G. (1999), The sorption of lead(II) ions on peat. Water Research, 33 (2) , 578-584. DOI: 10.1016/S0043-1354(98)00207-3.  

Document type: Article     Language: English     Cited references: 9     Times cited: 1025  

50.    Ho, Y.S. and McKay, G. (1999), A multi-stage batch sorption design with experimental data.

Adsorption Science & Technology, 17 (4), 233-243.  

Document type: Article     Language: English     Cited references: 41     Times cited: 39